Table 4. Correlation of MET mRNA assessed by RNA in situ hybridization with protein and gene copy number assessed by immunohistochemistry and silver in situ hybridization.
| RNA ISH score, n (%) | |||||
| 0 (n = 391) | 1 (n = 87) | 2 (n = 38) | 3 (n = 12) | 4 (n = 7) | |
| IHC score | |||||
| 0 (n = 236) | 205 (52.4) | 26 (29.9) | 5 (13.2) | 0 (0) | 0 (0) |
| 1 (n = 171) | 131 (33.5) | 26 (29.9) | 13 (34.2) | 1 (8.3) | 0 (0) |
| 2 (n = 113) | 54 (13.8) | 35 (40.2) | 18 (47.4) | 6 (50.0) | 0 (0) |
| 3 (n = 15) | 1 (0.3) | 0 (0) | 2 (5.3) | 5 (41.7) | 7 (100) |
| SISH | |||||
| DS (n = 221) | 190 (48.6) | 27 (31.0) | 4 (10.5) | 0 (0) | 0 (0) |
| LT (n = 130) | 96 (24.6) | 22 (25.3) | 12 (31.6) | 0 (0) | 0 (0) |
| HT (n = 1) | 1 (0.3) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| LP (n = 111) | 75 (19.2) | 23 (26.4) | 10 (26.3) | 3 (25.0) | 0 (0) |
| HP (n = 58) | 29 (7.4) | 15 (17.2) | 10 (26.3) | 3 (25.0) | 1 (14.3) |
| GA (n = 14) | 0 (0) | 0 (0) | 2 (5.3) | 6 (50.0) | 6 (85.7) |
Abbreviations: DS, disomy; GA, gene amplification; HP, high polysomy; HT, high trisomy; IHC, immunohistochemistry; ISH, in situ hybridization; LP, low polysomy; LT, low trisomy; SISH, silver in situ hybridization.