Table 5. Simultaneous comparison of MET status evaluated by RNA in situ hybridization, immunohistochemistry and silver in situ hybridization.

RNA ISH scores	IHC scores	SISH patterns, n (%)
		Non-GA (n = 521)			GA (n = 14)
		DS, TS (n = 352)	LP (n = 111)	HP (n = 58)
0/1	0/1	291 (82.7)	73 (65.8)	24 (41.4)	0 (0)
0/1	2	45 (12.8)	25 (22.5)	19 (32.8)	0 (0)
0/1	3	0 (0)	0 (0)	1 (1.7)	0 (0)
2	0/1	9 (2.6)	6 (5.4)	3 (5.2)	0 (0)
2	2	7 (2.0)	4 (3.6)	5 (8.6)	2 (14.3)
2	3	0 (0)	0 (0)	2 (3.4)	0 (0)
3/4	0/1	0 (0)	0 (0)	1 (1.7)	0 (0)
3/4	2	0 (0)	3 (2.7)	2 (3.4)	1 (7.1)
3/4	3	0 (0)	0 (0)	1 (1.7)	11 (78.6)

Abbreviations: DS, disomy; GA, gene amplification; HP, high polysomy; IHC, immunohistochemistry; ISH, in situ hybridization; LP, low polysomy; SISH, silver in situ hybridization; TS, trisomy.