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. 2014 Nov 3;9(11):e111665. doi: 10.1371/journal.pone.0111665

Figure 3. Effect of One or Several Sertraline Doses on the Increase in IL-1β and TNF-α mRNA Expression Induced by 4-AP in the Hippocampus.

Figure 3

Relative IL-1β/β-actin (A) and TNF-α/β-actin (B) mRNA expression in the groups administered with a single injection of vehicle (G1) or with one daily injection of vehicle for one week (G3), and in groups injected with 2.5 mg/kg 4-AP and pre-administered with: a single injection of vehicle (G5), a single injection of 0.75 mg/kg sertraline (G6), or one daily injection of 0.75 mg/kg sertraline for one week (G7). Results are the mean ± SEM values of 6 (G5) or 4 (G6 and G7) animals per group.*, p = 0.01 and ***, p<0.001 between the dashed line connecting experimental conditions.