Table 2. SNPs showing associations with diabetic retinopathy (DR) in combined stages 1 and 2 samples with P<10−3 using the allele model.
| Stage 1+2 | Stage 1+2+3 | ||||||||||||||||||||||||
| RefSeq genes | ENCODE/GENECODE genes | Stage1 | Stage2 | Overallanalysis | Meta-analysis | Stage3 | Overallanalysis | Meta-analysis | |||||||||||||||||
| SNP | Chr/Position | Gene | Left gene | Right gene | Gene | Left gene | Right gene | Allele(Risk/Other) | OR | 0.399/0.351 | OR | P | OR | P | OR | Pmet | Phet | OR | P | RiskallelefrequencyDR(+)/DR(−) | OR | P | OR | Pmet | Phet |
| rs11582936 | 1/4909707 | NA | AJAP1 | MIR4417 | NA | AJAP1 | RP11-542C10.1 | C/A | 1.71 | 0.811/0.770 | 1.25 | 6.6×10−2 | 1.43 | 8.4×10−5 | 1.43 | 8.8×10−5 | 9.0×10−2 | 1.08 | 6.9×10−1 | 0.399/0.351 | 1.23 | 1.9×10−3 | 1.24 | 1.3×10−3 | 1.7×10−2 |
| rs17109215 | 1/54178200 | GLIS1 | DMRTB1 | NDC1 | GLIS1 | DMRTB1 | TMEM48 | A/G | 1.56 | 0.263/0.226 | 1.41 | 1.7×10−2 | 1.46 | 4.3×10−4 | 1.47 | 3.9×10−4 | 6.5×10−1 | 1.08 | 5.6×10−1 | 0.811/0.770 | 1.28 | 2.4×10−3 | 1.28 | 2.2×10−3 | 1.5×10−1 |
| rs4580644 | 4/15785201 | CD38 | BST1 | FGFBP1 | CD38 | BST1 | FGFBP1 | T/C | 1.62 | 0.347/0.305 | 1.41 | 1.1×10−2 | 1.51 | 5.7×10−5 | 1.50 | 7.4×10−5 | 4.9×10−1 | 0.88 | 3.0×10−1 | 0.263/0.226 | 1.22 | 6.9×10−3 | 1.20 | 1.8×10−2 | 2.9×10−3 |
| rs12641981 | 4/45179883 | NA | GNPDA2 | GABRG1 | NA | RP11-362I1.1 | U6 | T/C | 1.52 | 0.602/0.552 | 1.58 | 9.3×10−3 | 1.42 | 2.2×10−4 | 1.45 | 8.1×10−5 | 6.5×10−1 | 1.00 | 9.7×10−1 | 0.347/0.305 | 1.21 | 5.3×10−3 | 1.23 | 3.3×10−3 | 2.8×10−2 |
| rs1156082 | 6/77501140 | NA | IMPG1 | HTR1B | NA | RP11-35J1.1 | HTR1B | C/T | 1.69 | 0.365/0.291 | 1.29 | 3.2×10−2 | 1.45 | 3.4×10−5 | 1.44 | 3.8×10−5 | 1.3×10−1 | 0.97 | 7.8×10−1 | 0.602/0.552 | 1.21 | 4.0×10−3 | 1.21 | 3.7×10−3 | 4.3×10−3 |
| rs9362054 | 6/85178268 | NA | CEP162 | TBX18 | RP1-90L14.1 | KIAA1009 | RP11-132M7.1 | T/C | 1.84 | 0.867/0.846 | 1.52 | 7.1×10−4 | 1.67 | 4.4×10−8 | 1.64 | 1.4×10−7 | 3.2×10−1 | 1.06 | 6.2×10−1 | 0.365/0.291 | 1.40 | 1.1×10−6 | 1.36 | 1.7×10−5 | 5.6×10−3 |
| rs7083364 | 10/27196099 | NA | ABI1 | LINC00202-1 | NA | snoU13 | LINC00202-1 | T/G | 2.36 | 0.564/0.518 | 1.52 | 2.8×10−2 | 1.83 | 1.0×10−5 | 1.83 | 1.4×10−5 | 1.2×10−1 | 0.77 | 5.6×10−2 | 0.867/0.846 | 1.19 | 7.3×10−2 | 1.18 | 8.8×10−2 | 1.7×10−5 |
| rs10894267 | 11/130714861 | NA | C11orf44 | SNX19 | RP11-890B15.2 | C11orf44 | RP11-890B15.3 | T/C | 1.78 | 2.8×10−5 | 1.32 | 1.8×10−2 | 1.49 | 5.5×10−6 | 1.49 | 5.8×10−6 | 9.3×10−2 | 0.95 | 6.0×10−1 | 0.564/0.518 | 1.20 | 4.4×10−3 | 1.22 | 2.2×10−3 | 8.0×10−4 |