Table 3. Associations of rs9362054 in RP1-90L14.1 with diabetic retinopathy (DR), proliferative diabetic retinopathy (PDR) and diabetic nephropathy (DN) in each stage and combined stages 1, 2 and 3, using logistic regression under genotype, dominant and recessive models after adjusting for sex, duration of diabetes and HbA1c.
DR | PDR | DN | ||||||||||||||||||||||||
Stage 1+2 | Stage 1+2+3 | Stage 1+2+3 | Stage 1+2+3 | |||||||||||||||||||||||
Stage 1 | Stage 2 | Overallanalysis | Meta-analysis | Stage 3 | Overallanalysis | Meta-analysis | Overallanalysis | Meta-analysis | Overallanalysis | Meta-analysis | ||||||||||||||||
OR | P | OR | P | OR | P | OR | Pmet | Phet | OR | P | OR | P | OR | Pmet | Phet | OR | P | OR | Pmet | Phet | OR | P | OR | Pmet | Phet | |
genotype modela | 1.59 | 2.1×10−3 | 1.59 | 2.4×10−4 | 1.63 | 3.4×10−7 | 1.59 | 1.8×10−6 | 1.0×100 | 1.15 | 2.5×10−1 | 1.45 | 1.7×10−7 | 1.39 | 4.8×10−6 | 1.3×10−1 | 1.21 | 6.1×10−2 | 1.12 | 2.6×10−1 | 6.4×10−2 | 1.68 | 1.0×10−6 | 1.53 | 1.2×10−4 | 4.8×10−1 |
dominant model | 1.54 | 3.5×10−2 | 1.67 | 3.7×10−3 | 1.68 | 9.3×10−5 | 1.61 | 1.9×10−4 | 7.5×10−1 | 1.11 | 5.0×10−1 | 1.41 | 4.1×10−4 | 1.36 | 1.2×10−3 | 1.3×10−1 | 1.23 | 1.4×10−1 | 1.17 | 2.7×10−1 | 3.5×10−1 | 1.85 | 9.3×10−5 | 1.79 | 4.4×10−4 | 4.8×10−1 |
recessive model | 3.00 | 1.2×10−3 | 2.27 | 1.2×10−3 | 2.60 | 2.3×10−6 | 2.51 | 6.0×10−6 | 5.1×10−1 | 1.46 | 1.5×10−1 | 2.32 | 3.3×10−8 | 2.14 | 1.3×10−6 | 3.8×10−1 | 1.39 | 1.0×10−1 | 1.20 | 3.9×10−1 | 3.0×10−2 | 2.27 | 2.4×10−5 | 1.78 | 5.6×10−3 | 6.5×10−1 |
With additive genetic effect.