Table 4. Clinical and laboratory side effects.
| Day 15 | Month 1 | Month 2 | Month 3 | Month 6 | Month 9 | Month 12 | |
| Clinical side effects, n (%) | |||||||
| Skin, mucosa and nails | |||||||
| Hypersensitivity/Skin rash | 16(13) | 31(26) | 26(21) | 18(15) | 6(5) | 5(4) | 2(2) |
| Nail pigmentation | - | - | - | 2(2) | 7(6) | 9(8) | 9(9) |
| Gastro-intestinal | |||||||
| Nausea and vomiting, n (%) | 21(17) | 30(25) | 34(28) | 18(15) | 4(3) | 2(2) | 1(1) |
| Diarrhea, n(%) | 12(10) | 13(11) | 15(13) | 11(9) | - | - | - |
| Abdominal pain, n (%) | 4(3) | 1(1) | 2(2) | 1(1) | - | - | - |
| Neurological | |||||||
| Dizziness, n(%) | 3(2) | 6(5) | 6(5) | 6(5) | 2(2) | 2(2) | 1(1) |
| Insomnia, n(%) | - | - | - | 2(2) | 2(2) | 2(2) | 1(1) |
| Laboratory | |||||||
| Anemia (Hb<10 g/dl) | NA | NA | 19(16) | 6(5) | 4(3) | 2(2) | 2(2) |
| Liver functions elevated (ALT), n (%) | 7(6) | 13(10) | 8(7) | 8(7) | 3(3) | 2(2) | - |
| Other * , n (%) | 4(3) | 2(2) | 5(4) | 3(2) | 1(1) | - | - |
*other included fatigue, anxiety and nightmares.