Table 1.
Characteristics of the study population 1
| Age, y | 59.0 (45, 75) |
| Female | 544 (52.1) |
| Post-menopausal female | 446 (82.0) |
| Multivitamin users | 423 (40.7) |
| Current smokers | 134 (12.8) |
| BMI, kg/m2 | 27.2 (21.3, 38.5) |
| Alcohol use, g/d | 4.7 (0, 43.0) |
| Folic acid fortification status | |
| No | 319 (30.6) |
| Yes | 431 (41.3) |
| Not known | 294 (28.1) |
| Plasma /serum concentrations of metabolites | |
| Plasma folate nmol/L (n=1044) | |
| Exam 5 (1991–1995) | 13.1 (4.2, 46.0) |
| Exam 6 (1995–1998) | 22.6 (7.0, 61.4) |
| Mean of exams 5&6 (long-term) | 18.8 (6.8, 49.9) |
| Vitamin B-12 pmol/L | 293 (158.3, 544.7) |
| PLP (nmol/L) | 63.3 (24.9, 275.6) |
| Hcy µmol/L | 9.0 (5.7, 14.7) |
| Creatinine (µmol/L) | 102.5 (78.7, 133.5) |
1
n=1044, except for 4 missing values for multivitamin, values are median (5th, 95th percentiles) or n (%)