Overview of the simulator. Input data are the lesion database, the parcellated reference brain, and a set of simulation parameters. We ran the simulation for M3 and PM3 statistics separately for 100 critical region, varying systematically the sample size (N = 25, 50, 75, 100, 125, 150), proportion of lesions in the critical parcel that were accompanied by deficit probability (P = .25, .5, .75, 1), and significance threshold (Thr = .001, .005, .01, .05), for 100 iterations (T = 100).