Table 4.

Residual effects: The table indicates brain areas of significant increased or decreased connectivity with the listed networks for CRPS Patients visit 2 vs. Controls visit 2. Coordinates and max statistical value (z-stat) are given for peak activity as well as volume (Vol) of each cluster of activity. See Materials and methods for details.

	Brain region	Lat.	z-Stat	X (mm)	Y (mm)	Z (mm)	Vol (cm)
Salience
Positive (Patients visit 2 > Controls visit 2)	No statistically significant differences
Negative (Patients visit 2 < Controls visit 2)	Cortical
	Frontal
	Precentral	L	3.46	−50	−2	32	1.00
	Parietal
	Postcentral	L	3.18	−34	−38	60	1.18
	Temporal
	Inferior	R	3.51	54	−50	−12	2.12
Central executive network (CEN)
Positive (Patients visit 2 > Controls visit 2)	Cortical
	Occipital
		R	3.37	62	−34	−16	1.46
Negative (Patients visit 2 < Controls visit 2)	Cortical
	Parietal
	Postcentral	R	2.53	34	−34	48	1.20
	Occipital
	Calcarine	L	3.28	−10	−50	4	1.42
		R	2.63	6	−86	12	1.25
Default mode network
Positive (Patients visit 2 > Controls visit 2)	No statistically significant differences
Negative (Patients visit 2 < Controls visit 2)	Cortical
	Frontal
	Middle orbital	R	2.73	26	50	24	1.95
		R	3.07	34	34	36	1.06
		R	2.35	38	6	36	1.14
	Inferior orbital	R	3.82	30	34	−16	2.30
	Middle	L	3.22	−22	42	24	2.00
		L	2.39	−50	26	32	1.86
		L	3.05	−38	2	52	1.29
	Precentral	R	3.53	58	2	24	1.57
		L	3.00	−46	2	48	1.02
		L	3.85	−58	−2	36	1.44
		L	2.54	−34	−22	56	1.77
	Parietal
	Supramarginal	L	3.12	−62	−30	40	2.77
	Postcentral	L	3.60	−38	−38	64	3.45
	Precuneus	R	2.35	22	−46	12	1.19
	Occipital
	Superior	R	3.70	26	−78	20	8.43
	Middle	L	3.46	−22	−94	12	1.78
	Temporal
	Fusiform	L	2.79	−30	−6	−40	1.78
	Superior	R	3.58	62	−14	0	1.26
	Inferior	R	2.62	62	−38	−16	2.19
	Middle	L	3.15	−62	−54	16	1.28
		L	3.35	−54	−66	8	3.34
	Lingual	R	2.88	18	−66	−12	1.43
		L	3.06	−2	−66	4	3.09
	Parahippocampus
	Parahippocampal	L	3.33	−18	−6	−32	1.70
	Sub-cortical
	Putamen	R	3.73	30	2	0	2.68
	Brainstem/cerebellum
	msn	R	2.47	6	−34	−48	1.21
	Cerebellum 9	L	3.31	−18	−42	−52	2.26
	Cerebellum 4 5	R	3.93	10	−50	−8	1.66
	Cerebellum Crus 2	L	3.51	−18	−74	−36	2.08
		L	3.22	−6	−86	−32	1.26
	Cerebellum Crus 1	R	3.23	22	−74	−36	1.15
		L	3.90	−26	−86	−32	2.20
Sensorimotor network
Positive (Patients visit 2 > Controls visit 2)	No statistically significant differences
Negative (Patients visit 2 < Controls visit 2)	Cortical
	Parietal
	Precuneus	L	3.29	−6	−46	8	1.04
Cerebellum
Positive (Patients visit 2 > Controls visit 2)	No statistically significant differences
Negative (Patients visit 2 < Controls visit 2)	Cortical
	Frontal
	Superior medial	R	3.09	22	62	−8	1.56
	Middle	L	3.76	−30	10	64	1.28
	Superior	R	3.59	2	34	56	1.42
	Supp. motor area	R	3.43	10	−10	68	1.31
	Paracentral lobule	L	2.95	−10	−18	72	1.18
	Occipital
	Calcarine	L	3.18	−2	−98	4	1.64
	Superior	L	2.73	−18	−70	28	1.34
	Temporal
	Pole middle	R	3.43	38	18	−40	1.16
	Middle	R	2.61	62	−50	16	2.20
	Parahippocampus
	Parahippocampal	R	3.59	22	−2	−28	3.18
	Sub-cortical
	Caudate	L	2.85	−14	−2	20	1.01
	Brainstem / cerebellum
	Cerebellum_Crus 1	L	4.06	−38	−78	−20	3.46
Fronto-parietal network (right)
Positive (Patients visit 2 > Controls visit 2)	Cortical
	Frontal
	Frontal pole	R	2.95	2	58	0	3.46
	Superior medial	L	2.51	−10	50	32	2.02
	Superior orbital	R	3.03	14	2	72	1.27
	Middle orbital	R	2.58	26	38	32	1.75
		R	3.50	34	30	40	4.18
	Inferior orbital	R	3.19	38	38	−8	2.36
	Middle	L	3.27	−38	30	44	1.69
	Supp. motor area	L	2.53	−10	6	72	1.02
		L	2.72	−10	−14	52	1.51
	Paracentral lobule	L	3.68	−10	−30	64	2.26
	Parietal
	Postcentral	L	2.66	−42	−30	48	1.12
	Inferior	R	3.32	46	−38	56	2.22
		R	2.56	38	−38	48	1.66
	Precuneus	R	2.62	6	−66	60	1.06
	Occipital
	Calcarine	R	2.49	22	−90	0	1.38
	Middle	L	2.28	−18	−94	4	1.30
	Temporal
	Inferior	L	4.51	−42	2	−36	6.86
		L	3.10	−46	−46	−12	1.62
	Middle	L	2.26	−62	−18	−24	1.22
		R	3.44	62	−54	12	2.66
	Fusiform	R	3.70	26	−78	−4	2.69
	Superior	R	2.43	54	−46	20	2.50
	Cingulum
	Middle	L	2.60	−2	18	32	1.02
	Insula
	Posterior	L	2.52	−34	−26	20	1.19
	Parahippocampus
	Parahippocampal	L	3.20	−22	−10	−36	2.04
	Sub-cortical
	Putamen	R	3.20	30	6	8	3.29
	Hippocampus	R	3.05	38	−26	−8	1.09
	Brainstem/cerebellum
	Cerebellum 8	L	2.48	−34	−46	−48	1.15
	Cerebellum Crus 1	R	2.57	46	−54	−32	3.24
		L	2.68	−26	−74	−36	1.63
	Cerebellum 6	R	2.99	10	−70	−24	3.68
	Pons	L	3.08	−2	−18	−36	3.44
	Brainstem		2.52	2	−34	−32	2.17
Negative (Patients visit 2 < Controls visit 2)	Cortical
	Frontal
	Middle orbital	R	3.19	42	14	52	2.16
		R	3.06	30	−2	56	1.17
	Parietal
	Precuneus	L	3.01	−10	−50	24	1.21
	Occipital
	Rolandic operculum	L	1.73	−54	−6	8	1.25
	Temporal
	Superior	L	2.07	−54	−2	−4	1.10
	Inferior	R	3.00	50	−6	−32	1.43
	Lingual	R	2.10	22	−90	−12	1.39
	Sub-cortical
	Putamen	L	2.46	−14	10	0	2.17
	Hippocampus	R	2.58	34	−14	−24	1.03
	Brainstem/cerebellum
	Cerebellum 8	R	2.89	34	−42	−44	1.66
Fronto-parietal network (left)
Positive (Patients visit 2 > Controls visit 2)	No statistically significant differences
Negative (Patients visit 2 < Controls visit 2)	Cortical
	Frontal
	Superior	L	3.56	−22	10	64	1.69
	Brainstem/cerebellum
	Vermis 3		4.55	2	−46	−16	1.63