Table 5.
Treatment effects: Correlation with spontaneous pain scores: The table indicates brain areas of significant increased or decreased connectivity according to spontaneous pain scores in patients pre- and post-treatment. Brain areas of decreased connectivity with decreased pain scores appear in red–yellow, areas of increased connectivity with decreased pain scores appear in blue–light blue. Coordinates and max statistical value (z-stat) are given for peak activity as well as volume (Vol) of each cluster of activity. See Materials and methods for details.
| Brain region | Lat. | z-stat | X (mm) | Y (mm) | Z (mm) | Vol (cm) | |
|---|---|---|---|---|---|---|---|
| Salience | |||||||
| Positive (patients V1 > controls V1). | Cortical | ||||||
| Frontal | |||||||
| Middle_Orbital | R | 4.87 | 34 | 38 | 24 | 1.15 | |
| Middle_Orbital | R | 4.26 | 30 | 26 | 40 | 1.10 | |
| Inferior_Orbital | R | 7.08 | 50 | 22 | −4 | 1.50 | |
| Negative (increased connectivity with decreased pain) | Cortical | ||||||
| Frontal | |||||||
| Middle | R | 5.45 | 6 | 58 | −4 | 1.03 | |
| Superior_Orbital | R | 4.97 | 26 | 62 | 16 | 2.78 | |
| Rectus | L | 4.32 | −2 | 22 | −20 | 1.14 | |
| Inferior_Operculum | R | 4.32 | 50 | 6 | 20 | 3.44 | |
| Occipital | |||||||
| Rolandic_Operculum | L | 4.34 | −46 | 2 | 12 | 1.50 | |
| Temporal | |||||||
| Superior | R | 3.98 | 46 | −2 | −12 | 2.15 | |
| Superior | R | 3.51 | 38 | −30 | 12 | 1.17 | |
| Subcortical | |||||||
| Hippocampus | L | 5.00 | −14 | −10 | −20 | 1.20 | |
| Central executive | |||||||
| Positive (decreased connectivity with decreased pain) | Cortical | ||||||
| Temporal | |||||||
| Parahippocampus | R | 4.90 | 22 | 10 | −24 | 3.84 | |
| Negative (increased connectivity with decreased pain) | Cortical | ||||||
| Frontal | |||||||
| Middle | R | 4.87 | 10 | 46 | −12 | 1.42 | |
| Inferior_Orbital | L | 4.92 | −42 | 42 | −16 | 1.20 | |
| Inferior_Triangular | R | 3.38 | 54 | 26 | 0 | 2.02 | |
| Inferior_Orbital | L | 6.84 | −26 | 26 | −12 | 4.72 | |
| Cortical | |||||||
| Frontal | |||||||
| Parietal | |||||||
| Postcentral | L | 5.05 | −46 | −10 | 28 | 1.23 | |
| Postcentral | L | 4.00 | −54 | −18 | 36 | 1.96 | |
| Occipital | |||||||
| Middle | L | 3.51 | −42 | −74 | 16 | 1.04 | |
| Superior | L | 6.64 | −18 | −86 | 8 | 1.56 | |
| Temporal | |||||||
| Middle | L | 3.69 | −58 | −18 | 0 | 1.28 | |
| Middle | L | 3.91 | −58 | −34 | 4 | 1.22 | |
| Middle | L | 3.64 | −54 | −34 | −8 | 1.70 | |
| Middle | R | 5.73 | 42 | −58 | 12 | 1.18 | |
| Middle | R | 3.83 | 42 | −70 | 8 | 1.50 | |
| Inferior | L | 3.46 | −50 | −22 | −20 | 1.70 | |
| Fusiform | L | 6.94 | −30 | −50 | −8 | 2.92 | |
| Parahippocampal | R | 3.83 | 38 | −30 | −16 | 3.86 | |
| Cingulate | |||||||
| Middle | L | 3.97 | −10 | 2 | 44 | 1.09 | |
| Middle | R | 10.77 | 6 | −38 | 32 | 1.86 | |
| Middle | L | 8.11 | −6 | −38 | 44 | 1.22 | |
| Subcortical | |||||||
| Putamen | R | 4.06 | 18 | 14 | 0 | 1.08 | |
| Brainstem/cerebellum | |||||||
| Cerebellum_Crus 2 | R | 3.63 | 22 | −78 | −40 | 1.16 | |