Fig. 1.

Sample image with manual segmentation of regions of interest (ROI) on the first echo of the T2 relaxation experiment used to determine myelin water fraction. ROIs were manually outlined bilaterally, as demonstrated below on the single hemisphere. Note that regions of interest were conservatively selected to ensure exclusion of non-white tissues. Regions: a) Minor forceps (frontal white matter), b) genu, c) anterior internal capsule, d) posterior internal capsule, e) splenium, and f) major forceps (parieto-occipital white matter).