Table 2.
Gene ontology enrichment for the frontal cortex (BA4 region) network
| Module | cor | GO-term (DAVID) | Potential regulators |
|---|---|---|---|
| FC4pos1 | up | inflammatory response (6.64, 0.000) | MEF2 (0.041)1, NFkB (0.041)1, miR34 (0.050)1, let7 (0.041)1 |
| metallothionein (4.02, 0.04) | STAT3 (0.005)2, STAT5B (0.005)2, JUN (0.040)2 | ||
| regulation of transcription (3.58, 0.018) | |||
| regulation of apoptosis (3.25, 0.02) | |||
| vasculature development (2.7, 0.021) | |||
| cation homeostasis (2.68, 0.014) | |||
| IκB/NFκB (2.65, 0.02) | |||
| FC4pos2 | up | RNA binding/splicing (2.36, 0.037) | E2F (0.006)2, TLX2 (0.006)2, XBP1 (0.008)2, YY1 (0.011)2, HSF1 (0.021)2, LEF1 (0.021)2, MYC (0.021)2, SOX5 (0.025)2, AR (0.031)2 |
| FC4pos3 | up | amino acid catabolic process (5.52, 0.005) | miR155 (0.018)1 |
| fatty acid metabolism (3.25, 0.011) | MEF2 (0.038)2 | ||
| FC4pos4 | up | protein folding/chaperones (3.75, 0.001) | miR1 (0.009)1, HSF1 (0.009)1 |
| HSF1 (0.000)2, NFIL3 (0.033)2, STAT1 (0.037)2, SF1 (0.037)2, NFY (0.039)2 | |||
| FC4neg1 | down | protein transport (2.07, 0.03) | EVI1 (0.011)2, E4F1 (0.045)2, XBP1 (0.045)2, ATF2 (0.045)2 |
| FC4neg2 | down | membrane proteins (1.49, 0.2) | |
| FC4neg3 | down | fibronectin (1.6, 0.84) | |
| FC4neg4 | down | zinc-finger (1.74, 0.84) | |
| mitochondrion (6.01, 0.000) | |||
| proteasome/ubiquitin system (5.01, 0.000) | NRF1 (0.036)1 | ||
| FC4neg5 | down | glycolysis (3.5, 0.001) | ELK1 (0.000)2, SP1 (0.000)2, SF1 (0.001)2, E4F1 (0.001)2, TCF11 (0.005)2, ATF (0.007)2, JUN (0.007)2, NRF1 (0.007)2, CREB (0.028)2 |
| protein folding/chaperones (3.04, 0.015) | |||
| protein transport (3.0, 0.002) | |||
| HTT | n.a. | cytoskeleton (1.43, 0.18) |
Gene ontology (GO) enrichment for the frontal cortex BA4 region network. Genes in the identified modules were analyzed using DAVID. The sign of the correlation (cor) with HD and the over-represented GO-terms are shown. The first number in brackets after the GO-term is the respective fold enrichment, the second number the adjusted P-value, as determined by DAVID. All significantly enriched (adjusted P <0.05) GO-terms are shown. In cases where no significantly enriched GO-term was identified, the GO-term with the highest fold enrichment is shown. Potential regulators of a module were identified using 1GO-Elite, or 2WebGestalt. Adjusted P-values are given in brackets after the name. Regulators that were identified by both tools are highlighted in bold. HTT is part of a module, which is not correlated with HD in the frontal cortex BA4 region network. The GO-term enrichment for 100 genes with the highest correlation with HTT is shown. The GO-term enrichment for the frontal cortex network with BA4 and BA9 regions combined is shown in Additional file 11.