Table 1.
Cam-CAN exclusion criteria: conditions assessed at stage 1 interview that could result in exclusion, listed by category
| Exclusion category | Exclusion criteria |
|---|---|
| Cognitive health | MMSE score 24 or less (calculated in interview) |
| Missing MMSE scores (assumed to be 24 or less) | |
| Severe memory defect | |
| Consent difficulties for next stage | |
| Communication difficulties | Hearing problems (difficulty completing interview with hearing aid; inability to hear 35 db at 1000 Hz in either ear in interview functional hearing screening; hearing aid that cannot be removed) |
| Insufficient English language (native language not English and not bilingual English from birth) | |
| Vision difficulties (correct near vision of 20/100 or worse with both eyes) | |
| Medical problems (self-report of diagnosis) | Dementia diagnosis/Alzheimer’s Disease |
| Parkinson’s disease | |
| Motor Neurone disease | |
| Multiple Sclerosis | |
| Cancer (history of brain tumour or chemotherapy/radiotherapy for any cancer in last 6 months) | |
| Stroke | |
| Encephalitis | |
| Meningitis | |
| Epilepsy | |
| Head injury with serious results (coma, unconscious for >2 hrs, or skull fracture) | |
| Recently diagnosed or uncontrolled high blood pressure | |
| Pregnancy or trying to become pregnant | |
| Current serious psychiatric conditions (bipolar disorder, schizophrenia, or psychosis) | |
| Mobility problems | Restricted mobility which would prevent further participation |
| Inability to walk 10 metres | |
| Substance abuse | Past or current treatment for drug abuse |
| Current drug usage | |
| Refusal to answer substance abuse questions | |
| Specific MRI/MEG safety and comfort exclusions | Heart operation |
| Blood vessel procedure or device (carotid artery vascular clamp; venous umbrella; stent, filter or coil; Swan-Ganz catheter; vascular access ports or catheters) | |
| Neurostimulator or spinal fusion stimulator | |
| Electrodes on body, head or brain | |
| Pump, Implant or pacemaker | |
| Brain Operation | |
| Metal splinters in eye, head or ear | |
| Shrapnel, buckshot or bullet in body | |
| Wire sutures or surgical staples | |
| Artificial joints that are MRI incompatible (jaw/maxillary reconstruction; shoulder prosthesis; any other joint replacement surgery in the last 3 months) | |
| Bone fixation rods or plates in jaw, head, shoulders or spine | |
| Non-removable dental brace | |
| Non-removable prosthesis or removable eye prosthesis | |
| Inability to lie flat for an hour | |
| Claustrophobia | |
| Body piercings that cannot be removed | |
| IUD that is MRI incompatible | |
| Transdermal delivery patches that cannot be removed | |
| Tattoos on head face or neck |