Table 2.
Toxicity
| Toxicity (n = 12) | No. of patients (%) |
|||
|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Hematological | ||||
| Anemia | 1 (8.3) | 4 (33.3) | 6 (50.0) | 1 (8.3) |
| Leukopenia | 8 (66.7) | 2 (16.7) | 1 (8.3) | 0 (0) |
| Neutropenia | 0 (0) | 4 (33.3) | 4 (33.3) | 0 (0) |
| Febrile neutropenia | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Thrombocytopenia | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Non-hematological | ||||
| stomatitis | 2 (16.7) | 1 (8.3) | 0 (0) | 0 (0) |
| Nausea and vomiting | 2 (16.7) | 2 (16.7) | 0 (0) | 0 (0) |
| Diarrhea | 0 (0) | 1 (8.3) | 2 (16.7) | 0 (0) |
| Constipation | 1 (8.3) | 0 (0) | 0 (0.0) | 0 (0) |
| Fatigue | 3 (25.0) | 6 (50.0) | 1 (8.3) | 0 (0) |
| Alopecia | 5 (41.7) | 6 (50.0) | NA | NA |
| Edema | 4 (33.3) | 0 (0) | 0 (0) | 0 (0) |
| Nail change | 3 (25.0) | 3 (25.0) | 0 (0) | NA |
| Hand foot syndrome | 1 (8.3) | 1 (8.3) | 0 (0) | NA |
| Liver dysfunction | 5 (41.7) | 0 (0) | 0 (0) | 1 (8.3) |
| Neurotoxicity | 0 (0) | 0 (0) | 1 (8.3) | 0 (0) |
NA = not applicable.