Table 2.
Rutgers-CINJ Active Surveillance Protocol
| Inclusion Criteria | Follow-up Methods | Disease Progression |
|---|---|---|
| •PSA < 10 | •Pelvic MRI at diagnosis | •Increased Gleason score |
| •Gleason score ≤ 6 without grade 4 or 5 | •Confirmatory biopsy in 3-6 months | •Increase in number of positive cores |
| •Clinical stage ≤ T2a | •Repeat biopsies at year 1, 3, and 5 after confirmatory biopsy | •PSADT < 3 years |
| •≤ 3 positive cores | •PSA every 3 months for year 1, then every 6 months thereafter | •If pelvic MRI is positive |
| •≤ 50% cancer involvement in any core | •Pelvic MRI at year 1, 3, and 5 immediately prior to biopsy. If positive, intervention without further diagnostic tests. |
PSA=prostate-specific antigen, GS=Gleason score, PSADT=prostate-specific antigen doubling time, MRI=magnetic resonance imaging.