Response of LAPC4 xenograft tumors to androgen manipulation. A. Tumor volume in testes-intact (I) and castrated (C) at day 0 and day 14 post-castration. Values expressed as percentage of original volume (200 mm3). B. Response of LAPC4 tumors to 4 days of treatment. Tumor volume at day 0, day 14 and day 18 post-castration (4 days after pellet implant). Testes-intact (I), testes-intact plus dutasteride (I+D), castrated (C), castrated with testosterone replacement (C+T), castrated + dutasteride (C+D), castrated + testosterone replacement + dutasteride (C+T+D). Number of animals in each group is listed in parentheses. Values are expressed as mean ± SEM. (*, P < 0.05; **, P < 0.01).