Table 1.

Preclinical anti-IL-6 therapy effects in prostate cancer models

Cellular/xenograft model	Therapy effect	Reference Nr.
PC-3	Induction of apoptosis, inhibition of in vivo growth	48
PC-3M	Inhibition of cachexia	49
LNCaP-IL-6+	Insignificant inhibition of in vivo growth, decrease of Ki67-positive cells	51
LuCaP-35	Delayed tumor progression, blocked orchiectomy, induced p300/CBP expression	50