Table 2.

One-pot synthesis of α-substituted ketones via tandem allylic substitution/oxidation.

Entry	Allyl acetate		α-Substituted ketones		Yield (%)[a]
1	1a			3a	85
2	1a			3b	82
3	1a			3c	81
4	1a			3d	75
5	1f			3e	65
6	1f			3e	78[b]

^[a]Yield of purified and isolated products.

^[b]Allylic substitution carried out with Pd(OAc)₂ (5 mol %) and PPh₃ (10 mol %) at rt, and oxidation carried out with 3 equiv of NaBO₃·H₂O in THF/H₂O (1:1) at rt.