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. 2014 Jul 3;146(5):1274–1285. doi: 10.1378/chest.14-0106

TABLE 3 ] .

Baseline Values (± SD) and Changes (Least Squares Mean) From Baseline in Secondary Hemodynamic Parameters

Parameter Placebo (n = 11) Riociguat Treatment Difference (95% CI)a
0.5 mg (n = 8) 1 mg (n = 7) 2 mg (n = 10)
Baseline Change Baseline Change Baseline Change Baseline Change
Cardiac index, L/min/m2 2.2 ± 0.8 0.04 2.7 ± 0.5 0.1 2.6 ± 0.9 0.3 2.5 ± 0.5 0.5 0.4 (0.2 to 0.7)
P = .001
Cardiac output, L/min 4.2 ± 1.9 0.08 5.0 ± 0.7 0.3 5.2 ± 1.9 0.6 4.9 ± 1.5 1.0 0.9 (0.3 to 1.4)
P = .002
Diastolic BP, mm Hg 62.3 ± 11.9 −2.4 57.4 ± 9.7 −2.4 61.0 ± 10.2 −5.8 58.7 ± 11.2 −8.7 −6.3 (−11.8 to −0.7)
P = .03
Systolic BP, mm Hg 129.5 ± 20.2 −2.1 143.3 ± 19.3 −2.8 144.7 ± 22.8 −16.3 141.6 ± 24.9 −13.7 −11.7 (−22.4 to −0.9)
P = .03
Heart rate, bpm 66.1 ± 14.1 2.3 63.4 ± 12.2 0.9 73.0 ± 28.5 −0.2 67.5 ± 7.6 4.6 2.3 (−4.4 to 9.0)
P = .5
Stroke volume, mL 66.6 ± 34.0 0.6 81.5 ± 18.0 5.2 77.8 ± 36.7 4.0 75.1 ± 27.1 9.4 8.8 (0.4 to 17.3)
P = .04
Stroke volume index, mL/m2 34.2 ± 14.3 0.4 42.9 ± 7.9 2.6 39.1 ± 17.1 2.2 38.4 ± 10.4 4.6 4.2 (−0.1 to 8.4)
P = .05
Systemic vascular resistance, dyn/s/cm5 1,583 ± 689 −90 1,246 ± 392 −113 1,352 ± 795 −366 1,294 ± 481 −336 −247 (−490 to −4)
P < .05
Systemic vascular resistance index, dyn/s/cm5/m2 2,938 ± 1127 −170 2,356 ± 797 −229 2,581 ± 1,379 −691 2,398 ± 633 −624 −455 (−905 to −4)
P < .05
Pulmonary vascular resistance, dyn/s/cm5 303.5 ± 168.8 −4.6 217.1 ± 60.5 −5.7 223.7 ± 169.5 −28.2 227.7 ± 105.7 −20.8 −16.2 (−78.2 to 45.9)
P = .6
Pulmonary vascular resistance index, dyn/s/cm5/m2 554.5 ± 265.6 −6.4 417.5 ± 140.6 −13.1 435.9 ± 317.4 −53.2 425.0 ± 178.0 −39.4 −33.0 (−147.2 to 81.3)
P = .6
Pulmonary arterial wedge pressure, mm Hg 21.1 ± 6.4 −2.8 18.6 ± 2.1 −1.7 19.4 ± 2.1 0.1 21.8 ± 4.6 −2.9 −0.2 (−3.0 to 2.6)
P = .9
Right atrial pressure, mm Hg 11.6 ± 3.0 −0.9 9.5 ± 3.1 −0.7 12.7 ± 4.6 0.5 11.7 ± 4.4 −1.7 −0.8 (−3.9 to 2.2)
P = .6
Mean arterial pressure, mm Hg 83.9 ± 15.9 −4.3 85.0 ± 11.9 −4.1 86.0 ± 13.1 −9.3 85.6 ± 14.8 −12.3 −8.0 (−15.5 to −0.6)
P = .04
Mixed venous oxygen saturation, % 60.4 ± 7.8 1.2 66.6 ± 7.3 −1.1 67.8 ± 5.4b 3.1 64.3 ± 5.3c 2.5 1.3 (−3.2 to 5.8)
P = .6
Transpulmonary pressure gradient, mm Hg 13.8 ± 5.6 −0.1 13.4 ± 3.1 0.4 11.7 ± 4.9 0.9 13.3 ± 6.3 0.7 0.8 (−2.2 to 3.9)
P = .6

The mean changes from baseline of all evaluations up to 6 h after study drug administration are shown. bpm = beats/min.

a

Riociguat 2 mg vs placebo.

b

n = 6.

c

n = 9.

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