Skip to main content
. Author manuscript; available in PMC: 2015 Feb 7.
Published in final edited form as: Org Lett. 2014 Jan 16;16(3):724–726. doi: 10.1021/ol403402h

Table 4.

Gold-catalyzed Dehydrative Spirocyclization of Triols 6.

graphic file with name nihms557519u5.jpg
entry 6 R1 R2 n [Au] time (h) 7/yielda (%)
1 6a Ph H 0 Ph3PAuCl 5 7a (89)
2 6b Ph Me 0 Ph3PAuCl 4 7b (11)
3 6b Ph Me 0 Bb 4 7b (22)c
4 6b Ph Me 0 Cd 4 7b (46)
5 6c H Me 1 Ph3PAuCl 12 7c (64)e
a

Isolated yield.

b

B = [c-Hex2(o-biphenyl)]PAuCl.

c

40 °C.

d

C = [t-Bu2(o-biphenyl)]PAuCl.

e

19% reisolated starting material.