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. 2014 Nov 4;34(6):e00147. doi: 10.1042/BSR20140075

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© 2014 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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New possible angiogenic targets in STS are represented. The yellow boxes indicate the targets for new drug development for STS. TIMP2- synthetic peptides could block or retard extra-cellular matrix degradation, a crucial step in tumour cells migration. Monoclonal antibodies against FGF2 and CSF-1 could interfere with the endothelial cells activation and the consequent new-angiogenesis, a crucial step for tumour mass survival and metastatization. The use of small molecule directed to the FGF2-receptor could have an analogue effect. PIGF analogues could normalize the tumour vessel blocking tumour cells extravasation.