Table 1. Overview of different angiogenic factors and their correlation with STS prognosis.

The table summarizes the principal angiogenic factors and their correlation, were reported, with STS prognosis (+). Prognosis information missed or incomplete are indicated with -. VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor; PDGF, platelet derived growth factor; PlGF, placenta growth factor; IGF, insulin-like growth factor; Ang, angiopoietin; EGF, epidermal growth factor; HGF, hepatocyte growth factor; HIF, hypoxia-inducible factor; TGF, transforming growth factor; TNF, tumour necrosis factor; IL, interleukin; NP, neuropilin; SDF, stromal cell-derived factor; TSP, thrombospondin; PF, platelet factor; TIMP, tissue inhibitor metalloproteinase.

Category	Major functions	Names	Correlation with prognosis	Reference(s)
Angiogenesis inducers	Induction of EC (endothelial cell) growth, proliferation and survival under stress; induction of migration of ECs during sprouting angiogenesis; increase vascular permeability of ECs; stimulate secretion of proteinases important for tumour invasion and progression; activate matrix degrading enzymes (e.g. metalloproteinases); recruitment of tissue infiltrating hematopoietic cells, modulates receptor-ligand interaction. HIF-1α and angiogenin are transcriptional controller of many of the factors indicated	VEGF-A	+	[8,9,50]
		VEGF-B	+	[8,10]
		VEGF-C	+	[8,11]
		VEGF-D	−	[8]
		FGF-1	−	[12]
		FGF-2	+	[13,55]
		PDGF	+	[9,14,15,55]
		PlGF	+	[8,16]
		IGF-I/II	−	[17]
		Ang-1	−	[18]
		EGF	+	[11,19]
		HGF	+	[20,21]
		HIF-1α	+	[11,22]
		TGF-α	−	[23]
		TGF-β	+	[24,25]
		TNF-α	−	[26]
		IL-1	−	[27]
		IL-8	+	[28]
		NP1/2	−	[29]
		Angiogenin	−	[30]
		SDF-1	−	[31]
Angiogenesis inhibitors	Inhibition of ECs proliferation and growth and induction of ECs apoptosis; inhibit ion of ECs migration and blood vessels maturation; inhibition of the metalloproteinases activity or uPa activity	TSP-1/2	−	[32,33]
		Angiostatin	−	[34]
		Endostatin	+	[35,36]
		Vasostatin	−	[37]
		PF-4	−	[38]
		Antiangiogenic Antithrombin III	−	[39]
		TIMPs	+	[40–43]
		Ang-2	−	[44,45]