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. 2014 Jul 11;4(7):e226. doi: 10.1038/bcj.2014.47

Table 3. Multivariate Cox regression analysis for EFS and OS.

  EFS OS
 
HR
95% CI
P-value
HR
95% CI
P-value
Total cohort (n=315)
 Mutation status, vs WT non-CBF
  CBF 0.31 0.19–0.49 <0.01 0.09 0.03–0.25 <0.01
  CEBPA-single 0.47 0.24–0.91 0.02 0.60 0.29–1.26 0.18
  CEBPA-double 0.33 0.14–0.76 0.01 0.30 0.09–0.94 0.04
 Age (+1 year) 1.00 0.97–1.03 0.86 1.03 0.99–1.07 0.17
 WBC (⩾50 000) 1.81 1.29–2.55 <0.01 1.50 0.96–2.33 0.07
Normal karyotype cohort (n=62)
 Mutation status, vs WT
  CEBPA-single 0.54 0.22–1.33 0.18 0.88 0.31–2.47 0.81
  CEBPA-double 0.28 0.08–0.95 0.04 0.49 0.11–2.17 0.35
 Age (+1 year) 0.95 0.89–1.02 0.14 0.94 0.86–1.02 0.13
 WBC (⩾50 000) 2.05 1.00–4.22 0.05 1.34 0.55–3.29 0.52

Abbreviations: CBF, core-binding factor; CEBPA, CCAAT/enhancer-binding protein alpha; CI, confidence interval; EFS, event-free survival; HR, hazard ratio; OS, overall survival; WBC, white blood cell count; WT, wild type.