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. 2014 Jul 11;4(7):e227. doi: 10.1038/bcj.2014.46

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(a) The levels of immunoglobulins in 5–8-month-old Eμ-HMGA2 transgenic mice are much lower to those of age-matched wild-type control mice. (b) Production of anti-KHL antibodies as indicated by circulating serum levels in transgenic mice was lower than that of wild-type counterparts. (c) The levels of tumor necrosis factor alpha and IL-6 in serum of Eμ-HMGA2 transgenic mice were greatly elevated relative to those of their wild-type littermates.