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GdIgA1 and its related immune complex with anti-glycan autoantibodies are prospective disease-specific surrogate markers in IgA nephropathy. Recent clinical and experimental studies show that GdIgA1 and auto anti-glycan antibodies may be derived from the mucosa bone marrow axis.
Abbreviations: GdIgA1, galactose-deficient IgA1; IC, immune complex; Ig, immunoglobulin; LN, lymph nodes.
