Table 1.

Hydrocodone pharmacokinetic parameters after a mean dose of 0.5 mg/kg hydrocodone bitartrate (equivalent to 0.3 mg/kg hydrocodone base) PO to six healthy Greyhounds.

Parameter	Units	Geometric Mean	Min	Median	Max
Dose (hydrocodone bitartrate)	mg/kg	0.50	0.45	0.48	0.58
AUC extrapolated	%	8.38	3.86	8.33	16.72
AUC inf	h*ng/mL	36.36	28.67	32.98	53.57
Cl/F	mL/min/kg	139.38	85.25	147.12	205.80
CMAX	ng/mL	11.73	7.64	12.20	20.60
T ½ λz	h	1.60	1.37	1.54	2.18
λz	1/h	0.433	0.318	0.450	0.506
MRT inf	h	2.89	2.54	2.83	3.55
TMAX	h	0.74	0.50	0.75	1.00
Vz/F	L/kg	19.33	12.50	18.93	31.42
Actual Dose	mg/kg	0.50	0.045	0.49	0.61