TABLE 3.
Parameter Estimates | Effect Size | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||||
Dropout, % | Min CAP | Type I error, % | βS | G11 | G12 | G22 | σ2e | 30% | 40% | 50% | 60% | 70% |
0 | 290 | 5 | 1.56 | 21.40 | 4.45 | 3.20 | 16.54 | 552 | 310 | 199 | 138 | 101 |
0 | 350 | 5 | 2.04 | 25.96 | 5.61 | 3.67 | 19.39 | 377 | 212 | 136 | 94 | 69 |
0 | 400 | 5 | 2.81 | 32.11 | 6.56 | 5.26 | 24.63 | 263 | 148 | 95 | 66 | 48 |
0 | 290 | 10 | 1.56 | 21.40 | 4.45 | 3.20 | 16.54 | 402 | 226 | 145 | 101 | 74 |
0 | 350 | 10 | 2.04 | 25.96 | 5.61 | 3.67 | 19.39 | 275 | 155 | 99 | 69 | 51 |
0 | 400 | 10 | 2.81 | 32.11 | 6.56 | 5.26 | 24.63 | 192 | 108 | 69 | 48 | 35 |
| ||||||||||||
10 | 290 | 5 | 1.56 | 21.40 | 4.45 | 3.20 | 16.54 | 591 | 332 | 213 | 148 | 109 |
10 | 350 | 5 | 2.04 | 25.96 | 5.61 | 3.67 | 19.39 | 404 | 227 | 145 | 101 | 74 |
10 | 400 | 5 | 2.81 | 32.11 | 6.56 | 5.26 | 24.63 | 281 | 158 | 101 | 70 | 52 |
10 | 290 | 10 | 1.56 | 21.40 | 4.45 | 3.20 | 16.54 | 431 | 242 | 155 | 108 | 79 |
10 | 350 | 10 | 2.04 | 25.96 | 5.61 | 3.67 | 19.39 | 295 | 166 | 106 | 74 | 54 |
10 | 400 | 10 | 2.81 | 32.11 | 6.56 | 5.26 | 24.63 | 205 | 115 | 74 | 51 | 38 |
| ||||||||||||
20 | 290 | 5 | 1.56 | 21.40 | 4.45 | 3.20 | 16.54 | 636 | 358 | 229 | 159 | 117 |
20 | 350 | 5 | 2.04 | 25.96 | 5.61 | 3.67 | 19.39 | 435 | 245 | 157 | 109 | 80 |
20 | 400 | 5 | 2.81 | 32.11 | 6.56 | 5.26 | 24.63 | 303 | 170 | 109 | 76 | 56 |
20 | 290 | 10 | 1.56 | 21.40 | 4.45 | 3.20 | 16.54 | 464 | 261 | 167 | 116 | 85 |
20 | 350 | 10 | 2.04 | 25.96 | 5.61 | 3.67 | 19.39 | 317 | 178 | 114 | 79 | 58 |
20 | 400 | 10 | 2.81 | 32.11 | 6.56 | 5.26 | 24.63 | 221 | 124 | 79 | 55 | 41 |
The single-arm sample size is for a treatment–placebo slope difference analyzed with linear mixed effects regression. Sample size is listed as a function of percentage of dropout, minimum CAP, Type I error rate, estimated parameters, and effect size. Details are provided in the Appendix.
Abbreviations: Min, minimum; CAP, age-CAG product.