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The combination of cationic liposome (GL67A) and plasmid DNA expressing CFTR (pGM169). (A) pGM169 plasmid encoding the gene for CFTR protein contains no CpG dinucleotides, which are unmethylated in bacterial derived plasmids and induce inflammatory response. The plasmid also includes a CMV promoter, which aids in increased gene expression. (B) Electron microscope image of pGM169-GL67A liposomal complex. Modified from http://www.genemedresearch.ox.ac.uk/ukcfgtc/product.html.
