Table I. The Effects of Metabolic Inhibitors and Uncoupler on the Lung Tissue Surface FAD and NADH Fluorescence Signals of Normoxic and Hyperoxic Rats.
Inhibitor/ Uncoupler | FAD % | NADH % | ||
---|---|---|---|---|
Normoxic | Hyperoxic | Normoxic | Hyperoxic | |
Rotenone | 0.2 ± 0.2 | −0.3 ± 0.3 | 20.2 ± 2.3 | 7.5 ± 1.0* |
KCN | −6.8 ± 1.6 | −5.2 ± 0.5 | 21.7 ± 2.5 | 9.2 ± 1.2* |
PCP | 1.7 ± 0.8 | −2.3 ± 1.4* | −19.7 ± 2.1 | −20.8± 1.2 |
PCP + KCN | −9.3 ± 1.0 | −4.2 ± 0.7 * | 25.7 ± 2.6 | 9.0 ± 1.0* |
Rotenone + KCN | 0.8–3.3 ± | −3.8 ± 0.6 | 4.6 ± 1.0 | 2.8 ± 1.2 |
Values are mean ± SE. For the (PCP + KCN) and (rotenone + KCN) treatments, the percentage change due to additional treatment with KCN is calculated relative to the new baseline in the presence of PCP or rotenone, respectively. For normoxic lungs, and 5 for rotenone, potassium cyanide (KCN), pentachlorophenol (PCP), PCP + KCN, and rotenone + KCN, respectively. For hyperoxic lungs , and 4 for rotenone, KCN, PCP, PCP + KCN, and rotenone + KCN, respectively.
* indicates value significantly different from the corresponding normoxic value (t-test ).