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. Author manuscript; available in PMC: 2014 Nov 4.
Published in final edited form as: Basic Clin Pharmacol Toxicol. 2007 Oct;101(4):262–268. doi: 10.1111/j.1742-7843.2007.00116.x

Fig. 2.

Fig. 2

Silymarin attenuates palmitate-induced cell death in HepG2 cells. (A) Silymarin protected HepG2 cells from palmitate-induced cell death in a dose-dependent manner. HepG2 cells were pre-treated with different dose of silymarin for 2 hr followed by 0.25 mM palmitate treatment for 20 hr. At least three experiments were conducted for each measurement. *Value is significantly different from that seen in control cells, P < 0.05. (B) Silymarin protects HepG2 cells from palmitate-induced lactate dehydrogenase (LDH) (U/l) release in a dose-dependent manner. HepG2 cells were pre-treated with a different dose of silymarin for 2 hr followed by 0.25 mM palmitate treatment for 20 hr. At least three experiments were conducted for each measurement. *Value is significantly different from that seen in control cells; †Value is statistically different from that seen in the absence of silymarin, P < 0.05.