Table 8.

Significant SNPs in the genome-wide association study of multiple substance dependencies. The symbol * indicates that the same SNP is also found by single-trait analysis in Table 7.

Chr	SNP	MAF	Gene	p-values
				T	T W,1	T W,2	${\widehat{T}}_{\text{IPW}}$
Black Men
2	rs2377339*	0.019	NCK2	1.1e-06	6.2e-08	1.4e-07	9.0e-07
5	rs251133	0.406	STARD4-AS1	5.3e-07	5.2e-06	2.8e-05	4.2e-07
5	rs10483285	0.037	ADCY4	2.4e-03	1.3e-07	5.0e-05	2.0e-03
White Men
3	rs4016435	0.042	CTNNB1	7.3e-07	6.2e-07	1.5e-07	2.6e-07
8	rs1477908	0.177	MMP16	1.1e-05	2.3e-05	2.3e-07	4.1e-06
Black Women
1	rs2175254	0.035	RASAL2	2.6e-05	4.1e-07	1.0e-05	1.7e-05
8	rs10504824	0.014	WWP1	1.1e-06	9.1e-09	2.7e-07	5.9e-07
8	rs17609515	0.014	CPNE3	1.1e-06	9.1e-09	2.7e-07	5.9e-07
10	rs7911634*	0.011	PCDH15	1.7e-04	1.1e-08	1.3e-05	1.6e-04
White Women
2	rs16866493	0.011	–	6.1e-04	1.9e-07	5.2e-04	3.3e-04
2	rs878167	0.010	–	1.3e-04	4.8e-08	1.0e-04	6.4e-05
2	rs6731600	0.039	–	2.1e-05	9.7e-06	7.1e-08	5.2e-06
2	rs6721762	0.039	MPV17	3.2e-05	1.1e-05	2.3e-07	8.7e-06
11	rs955396	0.068	TOLLIP/MUC5B	4.4e-05	1.5e-06	9.3e-08	4.4e-05
19	rs3745816*	0.016	EML2	5.2e-05	8.8e-10	1.7e-04	4.6e-05
19	rs4445998*	0.015	EML2	5.4e-05	3.8e-10	3.1e-04	4.6e-05
19	rs1545040*	0.020	EML2	6.7e-04	1.6e-07	2.4e-03	6.8e-04