Table 3. Association analyses of rs16835198 with clinical characteristics in normal weight controls.

rs16835198	TT (n = 537)	GT (n = 1192)	GG(n = 650)	β	SE	p	p *
Age (years)	50.36±15.25	50.51±14.42	50.66±15.39	0.1513	0.4327	0.727	/
BMI (kg/m2)	22.06 (20.52,23.34)	22.10 (20.58,23.45)	22.07(20.50,23.52)	0.0014	0.0012	0.261	/
Fasting plasma glucose(mmol/L)	5.03 (4.70,5.40)	5.00 (4.62,5.35)	5.00 (4.65,5.35)	-0.0004	0.0013	0.739	0.572
2-h plasma glucose (mmol/L)	5.49(4.54,6.21)	5.30 (4.52,6.20)	5.20 (4.55,6.12)	−0.0027	0.0028	0.328	0.211
Fasting insulin (mU/L)	5.46(3.94,7.65)	5.63 (4.07,7.73)	5.77 (3.98,7.94)	0.0178	0.0089	0.046	0.059
2-h insulin (mU/L)	24.21(15.45,43.63)	25.79 (13.50,41.75)	23.05 (14.08,41.29)	−0.0049	0.0124	0.691	0.498
Total cholesterol (mmol/L)	4.60(3.97,5.30)	4.65 (4.00,5.30)	4.55 (3.91,5.26)	−0.0027	0.0029	0.339	0.190
Triglyceride (mmol/L)	1.12 (0.83,1.64)	1.13 (0.81,1.62)	1.13(0.77,1.66)	−0.0027	0.0066	0.684	0.514
HDL-C (mmol/L)	1.37 (1.21,1.55)	1.36 (1.19,1.55)	1.35(1.15,1.56)	−0.0033	0.0028	0.238	0.198
LDL-C (mmol/L)	2.98(2.45,3.48)	3.01 (2.46,3.58)	2.91 (2.36,3.53)	−0.0060	0.0039	0.119	0.057
HOMA-IR	1.17 (0.85,1.71)	1.23 (0.86,1.66)	1.23 (0.83,1.72)	0.0172	0.0093	0.064	0.083
HOMA-B	80.00 (54.90,121.33)	84.81 (60.67,128.29)	87.07 (61.36,126.40)	0.0158	0.0102	0.124	0.128
Gutt-ISI	691.58(563.64,889.09)	697.61(573.72,903.39)	707.89(583.82,886.08)	0.0013	0.0054	0.813	0.589

Data are shown as mean±SD or median (interquartile range).

BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; HOMA-IR, homeostasis assessment model of insulin resistance;

HOMA-B, homeostasis assessment model of β-cell function; Gutt-ISI, insulin sensitivity index proposed by Gutt.

p values <0.05 are shown in bold, p values <0.1 are shown in italics.

*Adjusted for age, gender and BMI.