Table 2. Donor Characteristics.
| Total group | Low Bile Output | High Bile Output | P-value | |
| (n = 12) | (n = 6) | (n = 6) | ||
| Type of donor | 0.12 | |||
| DCD | 10 (83%) | 4 (67%) | 6 (100%) | |
| DBD | 2 (17%) | 2 (33%) | 0 (0%) | |
| Age (years) | 61 (50–64) | 55 (48–65) | 63 (51–65) | 0.47 |
| Gender | 0.22 | |||
| Male | 8 (67%) | 3 (50%) | 1 (17%) | |
| Female | 4 (33%) | 3 (50%) | 5 (83%) | |
| Height (m) | 1.77 (1.67–1.80) | 1.77 (1.64–1.81) | 1.78 (1.71–1.81) | 0.69 |
| Weight (kg) | 88 (76–98) | 90 (85–100) | 78 (75–95) | 0.20 |
| Reason for rejection | 0.25 | |||
| DCD + age>60 years | 5 (41%) | 1 (17%) | 4 (67%) | |
| DCD + high BMI | 3 (25%) | 2 (33%) | 1 (17%) | |
| DCD + other reason* | 2 (17%) | 1 (17%) | 1 (17%) | |
| Severe steatosis** | 2 (17%) | 2 (33%) | 0 (0%) | |
| Donor Risk Index | 2.35 (2.01–2.54) | 2.48 (2.23–2.61) | 2.20 (1.83–2.42) | 0.35 |
| ALT (U/L) *** | 38 (24–59) | 59 (34–104) | 25 (14–49) | 0.05 |
| GGT (U/L) *** | 90 (39–130) | 111 (62–144) | 65 (30–130) | 0.27 |
| Prothrombin time (sec) | 14.0 (12.3–16.3) | 15.0 (14.0–16.8) | 12.9 (9.1–39.7) | 0.20 |
| Preservation Solution | 1.00 | |||
| UW solution | 6 (50%) | 3 (50%) | 3 (50%) | |
| HTK solution | 6 (50%) | 3 (50%) | 3 (50%) | |
| Time between switch-off and cardiac death (min) | 24 (15–52) | 30 (2–53) | 24 (17–53) | 0.27 |
| Donor warm ischemia time (min) † | 17 (16–20) | 19 (9–26) | 17 (15–18) | 0.31 |
| Total donor warm ischemia (min) † | 43 (33–71) | 51 (27–72) | 43 (34–68) | 0.35 |
| Cold ischemia time (min) | 389 (458–585) | 530 (431–750) | 409 (363–473) | 0.11 |
| Liver weight (kg) | 2.09 (1.60–2.24) | 2.17 (1.60–2.31) | 2.03 (1.71–2.18) | 0.63 |
* One DCD donor with history of iv drug abuse (low bile output group) and one donor with prolonged s02<30% after withdrawal of life support (high bile output group).
** defined as macrovesicular steatosis with more than 60% of hepatocytes involved.
*** last known value before procurement.
Donor warm ischemia times was defined as the time interval between cardiac arrest and start of in situ cold perfusion. Total donor warm ischemia time was defined as the time interval between switch -off and start of in situ cold perfusion.
Continuous variables are presented as median and interquartile range, categorical variables are presented as numbers and percentage.
Abbreviations used: DCD, donation after cardiac death; DBD, donation after brain death; ALT, alanine aminotransferase; GGT, gamma glutamate transferase; UW, university of Wisconsin; HTK, Histidine- tryptophan-ketoglutarate.