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. 2014 Nov 4;9(11):e111418. doi: 10.1371/journal.pone.0111418

Figure 2. Circulating and hepatic mRNA levels of IGF-1 and FGF21 in CR mice.

Figure 2

Plasma A) IGF-1 and B) FGF21 levels in AL and CR mice at 2100 h or 2200 h (n = 16–21 per diet). Relative hepatic mRNA expression levels of C) IGF-1 and D) FGF21 in AL and CR mice at 2100 h or 2200 h (n = 29–31 per diet). Hepatic mRNA expression levels were normalized to 18S rRNA and then normalized to the AL group. Student's unpaired two-tailed t-tests were used for all between-group analyses (* p<0.05, ** p<0.0043, *** p<0.0001).