Figure 5. Global cell proliferation rates in WT and FGF21-KO mice fed AL or CR.

Fraction of new cells per day for A) keratinocytes, B) liver cells and C) splenic T-cells during the 3 week heavy water labeling period (n = 7–10 per genotype per diet). All between-group analyses were performed using a two-way ANOVA with a Bonferroni post hoc test (* p<0.05, ** p<0.01, *** p<0.001).