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. 2014 Nov 4;9(11):e111727. doi: 10.1371/journal.pone.0111727

Table 1. Summary of diagnostic accuracy estimates, higher study methodological quality*.

Type of test Pediatrics Adults
Immunochromatographic
Number of patients 10,325 1,216
Number of strata 28 6
Sensitivity, % 86 (85–87) 91 (87–94)
Specificity, % 96 (95–96) 93 (92–95)
Inconsistency (I2)
- Sensitivity 88% 61%
- Specificity 86% 72%
Enzyme Immunoassay (EIA)
Number of patients 342 333
Number of strata 3 2
Sensitivity, % 86 (79–92) 86 (81–91)
Specificity, % 92 (88–95) 97 (96–99)
Inconsistency (I2)
- Sensitivity 0% 88%
- Specificity 55% 88%
Optical immunoassay (OIA)
Number of patients 3,294 81
Number of strata 3 1
Sensitivity, % 80 (77–82) 94 (80–99)
Specificity, % 93 (92–94) 69 (54–81)
Inconsistency (I2)
- Sensitivity 67% -
- Specificity 90% -

*Numbers in parenthesis are 95% confidence intervals.