Table 1. Summary of diagnostic accuracy estimates, higher study methodological quality*.
Type of test | Pediatrics | Adults |
Immunochromatographic | ||
Number of patients | 10,325 | 1,216 |
Number of strata | 28 | 6 |
Sensitivity, % | 86 (85–87) | 91 (87–94) |
Specificity, % | 96 (95–96) | 93 (92–95) |
Inconsistency (I2) | ||
- Sensitivity | 88% | 61% |
- Specificity | 86% | 72% |
Enzyme Immunoassay (EIA) | ||
Number of patients | 342 | 333 |
Number of strata | 3 | 2 |
Sensitivity, % | 86 (79–92) | 86 (81–91) |
Specificity, % | 92 (88–95) | 97 (96–99) |
Inconsistency (I2) | ||
- Sensitivity | 0% | 88% |
- Specificity | 55% | 88% |
Optical immunoassay (OIA) | ||
Number of patients | 3,294 | 81 |
Number of strata | 3 | 1 |
Sensitivity, % | 80 (77–82) | 94 (80–99) |
Specificity, % | 93 (92–94) | 69 (54–81) |
Inconsistency (I2) | ||
- Sensitivity | 67% | - |
- Specificity | 90% | - |
*Numbers in parenthesis are 95% confidence intervals.