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. 2014 Nov 4;9(11):e111759. doi: 10.1371/journal.pone.0111759

Figure 5. CTL and Transcript levels of key enzymes in AA+ DCs and AA- DCs.

Figure 5

(A) CTL data of one representative sample i.e. killing of the target (MCF-7) cells by CTLs generated by AA+ DCs/AA- DCs pulsed with MCF-7 cell lysate. CTLs derived from AA+ DCs exhibited an improved effector function i.e. enhanced overall killing as compared to CTLs derived from AA- DCs. The killing is significantly higher at four ratios of effector target cell concentrations. (*P≤0.05, **P≤0.01, ***P≤0.001). (B) Gene expression profile of three key enzymes associated with AA pathway along with the housekeeping gene GAPDH. There is a substantial up-regulation of transcript level of key enzyme COX-2 in the DCs cultured in presence of AA.