Table 1. Tumorigenesis and targeted genes of the selected microRNAs in breast cancer and other human malignancies.

microRNA	Tumorigenesis	Role and targetedgenes	References
miR-10b	Breast cancer	Involved in invasion andcell motility Targets the 3′UTRof HOXD10. Upregulated byTwist and Snai1	[31]
miR-17	Breast cancer	Has an anti-apoptic role.Targets BRCA1 and P53 genes	[28], [32]
miR-21	Leukemia, lymphoma,breast, ovarian,cervical, colorectaland prostate cancer.	Plays a key role in resistingprogrammed cell death in cancercells. Invasion and metastasis,genome instability. It targets P53and other tumor suppressor genes	[33], [34], [35]
miR-34a	Breast cancer(Luminal A), prostate,pancreaticcancer	Targets 3′UTR of MAGE-Athat down regulates P53and Bcl-2.Plays a role as tumor suppressorgene in human pancreatic cancerwith loss of p53	[28]
miR-146a	Breast andcolorectal cancer	Downregulates BRCA1 (3′UTR)	[40]
miR-148a	Several cancer types	Downregulates C-MYC0, CDK6and TGIF2. It has been found to bedownregulated in several tumortypes and has been suggested tobe a tumor suppressor gene	[28]
miR-182	Breast and ovariancancer	Targets the 3′UTR of BRCA1.Downregulates PFN1. Involvedin the resistance of PARP inhibitors	[41]