miR-10b |
Breast cancer |
Involved in invasion andcell motility Targets the 3′UTRof HOXD10. Upregulated byTwist and Snai1
|
[31]
|
miR-17 |
Breast cancer |
Has an anti-apoptic role.Targets BRCA1 and P53 genes |
[28], [32]
|
miR-21 |
Leukemia, lymphoma,breast, ovarian,cervical, colorectaland prostate cancer. |
Plays a key role in resistingprogrammed cell death in cancercells. Invasion and metastasis,genome instability. It targets P53and other tumor suppressor genes |
[33], [34], [35]
|
miR-34a |
Breast cancer(Luminal A), prostate,pancreaticcancer |
Targets 3′UTR of MAGE-Athat down regulates P53and Bcl-2.Plays a role as tumor suppressorgene in human pancreatic cancerwith loss of p53
|
[28]
|
miR-146a |
Breast andcolorectal cancer |
Downregulates BRCA1 (3′UTR) |
[40]
|
miR-148a |
Several cancer types |
Downregulates C-MYC0, CDK6and TGIF2. It has been found to bedownregulated in several tumortypes and has been suggested tobe a tumor suppressor gene |
[28]
|
miR-182 |
Breast and ovariancancer |
Targets the 3′UTR of BRCA1.Downregulates PFN1. Involvedin the resistance of PARP inhibitors |
[41]
|