Circadian time course of motor activity in high-fat diet-fed interleukin-18 knockout (IL-18 KO) and wildtype (WT) mice. Data express M (+SEM) photocell interruptions in the x-dimension (horizontal activity, Panel A) or z-dimension (vertical activity, Panel B) by mature female mice averaged across 3-hr bins during a daily observation period in indirect calorimetry chambers. The grey shading indicates the dark cycle. Panels A and B illustrate that no significant main or interaction effects that involved Genotype were observed on motor activity measures. As expected, irrespective of genotype, motor activity was greater during the dark (vs. light) cycle and decreased across the dark cycle, but not light cycle (see Results for statistics).