Table 1.

Interleukin-18 genotype differences in body weight and weight change across the study period

Body weight measurement	IL-18 knockout (n = 7)	Wildtype control (n = 6)
Low-fat diet phase
Onset (g)	30.6 ± 2.2 *	23.1 ± 1.1
Completion (g)	30.3 ± 2.2 **	21.4 ± 0.6
Net daily change (dg/day)	−0.6 ± 0.8 ##	−3.5 ± 1.2
High-fat diet phase
Onset (g)	32.0 ± 2.0 **	23.1 ± 0.8
Completion (g)	34.1 ± 2.3 ***	22.7 ± 0.7
Net daily change (dg/day)	3.5 ± 0.7 ##, 1	−0.5 ± 0.8 1

Body weight progression of adult female Il18^−/− and wildtype littermate mice across the 5-day low-fat diet phase and 6-day high-fat diet phase of the study. Data are expressed as M ± SEM. Superscripts denote significant differences from wildtype controls

^*p < 0.05,

^**p < 0.005,

^***p = 0.001 (Student’s t-test),

^##p < 0.01 (main effect of Genotype) and from respective low-fat diet measure

¹p < 0.001 (main effect of Diet).