Table 2.

Specific metabolic drug reactions reported in zebrafish compared with humans

Drug metabolism in zebrafish		Similar to human	Human P450 isotype	Ref.
Compound	Reaction observed in zebrafish
Ibuprofen	Hydroxylation	Yes	CYP2C8/9	33
Paracetamol	Hydroxylation	Yes	CYP3A4	37
Testosterone	Hydroxylation	Yes	CYP3A4	37
Cisapride	Sulfate conjugation	No	CYP3A4	38
Verapamil	N-Dealkylation and hydroxylation	Yes	CYP3A4, CYP2C8/9, CYP1A2	38
Chlorpromazine	Hydroxylation, oxidation, N-demethylation, glucuronidation and sulfation	Yes	CYP1A2, CYP2D6	38
Phenacetin	De-ethylation	Yes	CYP1A2	38
Dextromethorphan	Demethylation	Yes	CYP2D6	38
Bupropion	Hydroxylation	Yes	CYP2B6	38