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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Hepatol Res. 2014 Jun 4;45(3):305–314. doi: 10.1111/hepr.12352

Figure 2.

Figure 2

Inhibition of ASM activity limits CCl4-induced hepatic fibrosis. (A) Sirius red staining of liver sections (magnification 50X) reveals increased collagen deposition over time in animals treated with CCl4 compared to animals treated with CCl4 and amitriptyline (TCA).

(B) Quantitation of hepatic fibrosis using pathological scoring. Decreased fibrosis in animals treated with CCl4 and TCA vs. CCl4 alone was confirmed via quantification of liver sections by a blinded pathologist. n=4–8 per group. Data are expressed as mean and SEM. *p<0.05 compared to all other groups. #p<0.05 compared to CCl4 group.