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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Hepatol Res. 2014 Jun 4;45(3):305–314. doi: 10.1111/hepr.12352

Figure 4.

Figure 4

Delayed treatment with amitriptyline (TCA) reduces CCl4-induced hepatic fibrosis. Sirius red staining of liver sections reveals progressive bridging fibrosis in animals treated with CCl4. In contrast, animals treated with CCl4 + TCA after establishment of fibrosis (TCA started after 5 weeks of CCl4 treatment) had significantly reduced hepatic fibrosis and slowed progression. (original magnification 50X) Quantitation of hepatic fibrosis using pathological scoring. Decreased fibrosis in animals treated with CCl4 and TCA in a delayed fashion vs. CCl4 alone was confirmed via quantification of liver sections by a blinded hepatopathologist. n=4–6 per group. Data are expressed as mean and SEM. *p<0.05 compared to all other groups, #p<0.05 compared to CCl4 alone group.