Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2014 May 4;1851(1):19–29. doi: 10.1016/j.bbalip.2014.04.008

Fig 7. Quantitative real time PCR analysis of ileum and liver mRNA expression in CYP7A1-tg and wild-type mice.

Fig 7

(A) Ileum mRNA expression of genes involved in bile acid metabolism and transport (Asbt, Ostα, Ostβ) and fatty acid β-oxidation (Pparα, Acad1, Ehhadh, Acaa1), and fatty acid transporter Cd36 in female chow-fed mice. (B) Hepatic mRNA expression of genes in bile acid metabolism (Cyp8b1), cholesterol efflux transporters (Abcg5, Abcg8) and fatty acid oxidation (Ehhadh, Acaa1) and fatty acid transport (Cd36) in female chow-fed mice. (C) Hepatic mRNA expression of enzymes in bile acid conjugation (Bacs and Bat), HNF4α, taurine biosynthesis (Taut and Csd) in chow fed female CYP7A1-tg mice. Data were expressed as mean ± SD. Significance comparison was based on two-tailed Student’s t-test or Mann-Whitney test. An *Indicates p<0.05 and an **indicates p<0.01 with respect to the wild-type (WT) group. Abbreviations: Tg, transgenic mice overexpressing CYP7A1 in the liver; WT, wild-type mice; Asbt, apical sodium-dependent bile acid transporter; Ostα, organic solute transporter-α; Ostβ, organic solute transporter-β; Pparα, peroxisome proliferator-activated receptor α; Acadl, long-chain specific acyl-CoA dehydrogenase; Ehhadh, enoyl-CoA hydratase/liter-3-hydroxyacyl-CoA dehydrogenase; Acaa1, acetyl-CoA acyltransferase 1; Abcg5, ATP-binding cassette G5; Abcg8, ATP-binding cassette G8; Cd36, fatty acid transporter; Taut, taurine transporter; Csd, cysteine sulfonic acid decarboxylase.