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(A) Adenocarcinoma from brain tissue after craniotomy at the time of initial diagnosis (H&E, ×400). (B) Large-cell neuroendocrine carcinoma (LCNEC) from rebiopsied sample (H&E, ×400). (C) LCNEC from rebiopsied sample (chromogranin, ×400). (D) LCNEC from rebiopsied sample (neuron specific enolase, ×400).
