Figure 7.

The effects of inactivation of Bmp4 from the mesenchymal tissues on the migration of OPCs into the cortex. To inhibit the expression of Bmp4 from the mesenchymal tissues, we used Pdgfrβ-Cre to ablate the Bmp4 allele in the mesenchymal tissues including meninges. A, Immunostaining of OPCs for Olig2 and Pdgfrα at E14.5. B, OPCs in the cortex were counted from the area above the line (n = 3). C, Immunostaining of OPCs for Olig2 and Pdgfrα at E17.5. D, OPCs in the cortex were counted from the area in the box (n = 3). Scale bars: 100 μm. Error bars depict SEM.