Table 3. Effect of ASA on EC50 and maximum dilation (Emax) values of Ach-induced relaxation of aortas of 6, 12, 18 month-old Control, and MS rats.
| Age (months) | Without ASA |
ASA |
|||
|---|---|---|---|---|---|
| EC50 (mol/L) | Emax (%) | EC50 (mol/L) | Emax (%) | ||
| Controls | 6 | 3.2×10−7±6.4×10−8 | 81.0±1.5 | 1.7×10−6±7.4×10−7c | 56.8±4.8c |
| 12 | 8.7×10−7±2.3×10−7 | 69.1±1.6 | 7.2×10−7±1.1×10−7 | 66.1±2.5 | |
| 18 | 1.4×10−6±4.2×10−7e | 59.0±1.6e | 1.1×10−6±3.8×10−7 | 57.9±1.3 | |
| MS | 6 | 4.1×10−7±7.3×10−8 | 63.7±2.2 | 4.3×10−7±5.0×10−8 | 64.9±1.7 |
| 12 | 4.1×10−7±9.4×10−8 | 69.6±2.2 | 4.2×10−7±6.7×10−8 | 66.7±3.4 | |
| 18 | 4.9×10−7±9.5×10−8 | 63.0±1.8 | 6.6×10−7±1.8×10−7 | 51.5±6.2c | |
Aortic rings were pre-constricted with NE 1 μmol/L. Changes in the maximum response (Emax, expressed as a percentage of relaxation) and EC50 to Ach in aortas from Control and MS rats. Values are mean±SEM. n=8. eP<0.05 vs other ages in the same group. cP<0.05 vs without treatment.