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. 2014 Sep 29;35(11):1428–1438. doi: 10.1038/aps.2014.68

Figure 6.

Figure 6

Fasudil shifts M1 to the M2 phenotype in vivo. Chronic EAE was induced in C57BL6 mice with MOG35-55 and fasudil was injected (ip) from d 3 pi till d 27 pi. Sections of the spinal cords were co-stained with anti-CD11b and anti-iNOS or anti-TNF-α, as well as with anti-CD11b and anti-arginase or anti-IL-10. The number of double-positive cells was observed in the lumbar enlargement of the spinal cord. The representative pattern was obtained from 1 of 3 experiments with similar results. Quantitative analysis was performed for 4–5 mice in each group. bP<0.05; cP<0.01.