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. 2014 Sep 29;35(11):1439–1446. doi: 10.1038/aps.2014.77

Figure 3.

Figure 3

Comparisons of wild type EGFR mAb and bisec-EGFR mAb in ADCC. ADCC was evaluated in EGFR-positive A431 cells at different effector:target cell (E:T) ratios. Compared to the wild type EGFR mAb, the bisec-EGFR mAb resulted in comparable effective specific lysis at a lower E:T ratio (P<0.05). At the same E:T ratio (40:1), the bisec-EGFR mAb resulted in effective specific lysis, with approximately three-fold greater lysis than that mediated by the wild type EGFR mAb (88% vs 30%, P<0.001). bP<0.05, cP<0.01.