Table 2. TGR5 and FXR activities of triterpenoids. Data are presented as mean±SEM (n=3).

Name	TGR5		FXR
	EC50/nmol·L−1	Efficacy	EC50/nmol·L−1
GW4064	–	–	48.82±0.4
INT-777	469.0±94.3	100.0±0.7	NR
8α	577.4±86.3	89.77±1.2	NR
8β	7082±453.6	87.67±1.3	NR
9α	3190±443.8	90.19±1.3	NR
9β	3979±994.1	93.04±0.8	NR
11α	237.8±73.6	91.63±0.4	NR
11β	1867±432.9	84.03±1.5	NR

EC₅₀ and efficacy generated from human TGR5-based cAMP assay or human FXR-based reporter assay. NR=No response at concentrations up to 100 μmol/L.